125-10-0 Pharmaceutical intermediate purity 99% prednisone acetate 125-10-0

1. When applied to patients with tuberculosis, acute bacterial or viral infections, appropriate anti-infective treatment must be given. 2. After taking the medicine for a long time, it should be gradually reduced when the medicine is stopped. 3. Patients with diabetes, osteoporosis, liver cirrhosis, renal dysfunction, and hypothyroidism should be used with caution. 4. For those infected with bacteria, fungi and viruses, they should be used with caution while applying sufficient amounts of sensitive antibiotics. Medication:Medications for pregnant and lactating women: The use of pregnant women can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. Animal experiments have teratogenic effects, and the pros and cons should be weighed. Nursing mothers who receive large doses should not breastfeed to prevent the excretion of drugs through milk, which can cause adverse effects such as infant growth inhibition and adrenal function inhibition. Children’s medication:Children who use adrenocortical hormones for a long time must be very cautious, because hormones can inhibit the growth and development of children. If long-term use is necessary, short-acting (such as cortisone) or intermediate-acting agents (such as prednisone) should be used. , Avoid using long-acting preparations (such as dexamethasone). Oral medium-effect preparations every other day can reduce the inhibitory effect on growth. Long-term use of glucocorticoids in children or adolescents must be closely observed. The risk of osteoporosis, ischemic necrosis of the femoral head, glaucoma, and cataracts in children is increased. In addition to the general age and weight, the dosage of hormones for children should also be based on the severity of the disease and the child’s response to treatment. For the treatment of children with adrenal insufficiency, the amount of hormones should be based on the body surface area, if it is determined by body weight, it is prone to Medication for the elderly: Glucocorticoids are prone to high blood pressure, and elderly patients, especially women after menopause, are prone to osteoporosis. medicine interactions:1. Non-steroidal anti-inflammatory analgesics can enhance its ulcer-causing effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. Combined with amphotericin B or carbonic anhydrase inhibitor, it can aggravate hypokalemia, long-term use with carbonic anhydrase inhibitor, prone to hypocalcemia and osteoporosis. 4. Combined with protein assimilation hormone, it can increase the incidence of edema and make acne worse. 5. Long-term use with anticholinergic drugs (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by them. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because it can increase the blood sugar of diabetic patients. 8. Thyroid hormone can increase its metabolic clearance rate, so the combination of thyroid hormone or antithyroid drugs should adjust the dosage of the latter appropriately. 9. Combined with contraceptives or estrogen preparations, it can strengthen its therapeutic effect and adverse reactions. 10. Combined with cardiac glycoside, can increase the occurrence of digitalis toxicity and heart rhythm disorders. 11. Combined with potassium excretion diuretics, can cause severe hypokalemia, and weaken the sodium excretion and diuretic effect of diuretics due to water and sodium retention. 12. Combined with ephedrine, it can enhance its metabolic clearance. 13. Combined with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14. Can increase the metabolism and excretion of isoniazid in the liver, reduce the blood concentration and therapeutic effect of isoniazid. 15. It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16. Combined with salicylate can reduce plasma salicylate concentration. 17. Combined with growth hormone, it can inhibit the latter’s growth promoting effect. Drug Toxicology:Adrenal cortex hormone drugs have anti-inflammatory, anti-allergic, anti-rheumatic, immunosuppressive effects. The mechanism of action is: 1. Anti-inflammatory effect: This product can reduce and prevent the tissue’s response to inflammation, thereby reducing the performance of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. 2. Immunosuppression: including preventing or inhibiting cell-mediated immune reactions, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, and reducing the ability of immunoglobulins to bind to cell surface receptors And inhibit the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes to lymphoblasts and reducing the expansion of the primary immune response. Can reduce the immune complex through the basement membrane, and can reduce the concentration of complement components and immunoglobulins. Pharmacokinetics: This product must show the pharmacological activity after reducing the 11-keto group to the 11-hydroxyl group in the liver, and the physiological half-life is 60 minutes. The distribution in the body is highest in the liver, followed by plasma, cerebrospinal fluid, pleural effusion, ascites, and kidney. In the blood, most of this product is bound to plasma proteins, and free and bound metabolites are excreted from urine, and some are excreted in the original form. A small portion can be discharged through breast milk. Storage: sealed from light