99% High Quality Ritonavir Powder 155213-67-5 with Best Price From Lingding

Melting point 120-122°C
Boiling point 947.0±65.0 °C(Predicted)
density 1.239±0.06 g/cm3(Predicted)
Fp 2℃
storage temp. room temp
solubility DMSO: soluble10mg/mL (clear solution, warmed)
pka 11.47±0.46(Predicted)
form powder
color white to beige
Water Solubility 5mg/L(ms)
Merck 14,8238




Categories:

Product Name: Ritonavir
Synonyms: 1,3-thiazol-5-ylmethyl n-[(2s,3s,5r)-3-hydroxy-5-[[(2s)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenyl-hexan-2-yl]carbamate;1,3-THIAZOL-5-YLMETHANOL;CHEMBRDG-BB 4050354;THIAZOL-5-YL-METHANOL;RITONAVIR;RARECHEM AL BD 1261;1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate;Ritonavir for peak identification
CAS: 155213-67-5
MF: C37H48N6O5S2
MW: 720.94
EINECS: 605-001-5
Mol File: 155213-67-5.mol

Ritonavir Structure

Description:

Norvir was launched in Germany, the UK and US for treatment of advanced HIV in combination with antiretroviral nucleoside analogs in a record 72 days by the FDA. It is an inhibitor of HIV aspartic protease which is critical in the processing of a propeptide into the gag, gag-pol gene products and the protease itself. This inhibition results in the release of non-infectous immature virus particles. It is greater than 500-fold more selective for viral aspartic protease than the human version, has good oral bioavailability and may increase the bioavailability of other protease inhibitors. Ritonavir was able to increase the CD4 and CD8 lymphocyte count as well as reduce viral RNA. It is more potent than saqunavir and comparible in potency to zidovudine and lamivudine.