Product name: 72509-76-3
CAS No.: 72509-76-3
Quality standard:Export standard
Assay: 99%min
MF:C18H19Cl2NO4
Use:calcium antagonist
Appearance: White Crystaline Powder
Specifications
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Tests |
Specifications |
Results |
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Description |
White to yellowish powder, very hygroscopic. |
Off-white powder, very hygroscopic. |
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Solubility |
Freetly soluble In water and methanol and dichloromethane |
Complies |
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Identification |
(1)By IR, To match with working standard |
Complies |
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| (2)It gives reaction of sodium |
Complies |
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Impurities A |
≤0.1% |
Not detected |
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Related compounds |
Any impurity ≤0.1% |
<0.1% |
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Total impurities ≤0.4% |
0.25% |
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Residual Solvents |
Acetidin≤ 0.5% |
Not detected |
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Dichloromethane≤ 0.06% |
Not detected |
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Methanol≤ 0.3% |
Not detected |
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Acetone ≤ 0.5% |
Not detected |
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Acetonitrile≤0.041% |
Not detected |
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Ethanol≤0.5% |
0.04% |
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N, N-dimethylformamide≤0.088% |
Not detected |
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Water |
≤ 5.0% |
1.38% |
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Assay |
99.0%-101.0%(On anhydrous basis) |
99.98% |
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Conclusion |
Conform to EP8.0 |
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Application:
Used for the treatment of high blood pressure is a selective calcium antagonists, inhibit the main flow of extracellular calcium arterial smooth muscle cells, and selective expansion of small arteries, veins, no such effect, not cause orthostatic hypotension; myocardial also. no significant inhibition. This product reduces renal vascular resistance, while not affect glomerular filtration rate and creatinine clearance rate, renal blood flow did not change even slightly increased, there natriuretic and diuretic effect. It can be used to increase output and cardiac index, significantly reducing afterload, while the systolic function, preload and heart rate had no significant effect.
