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CAS No.:72509-76-3
Other Names:72509-76-3
MF:C18H19Cl2NO4
EINECS No.:620-472-7
Place of Origin:Hebei,China

Product name: 72509-76-3
CAS No.: 72509-76-3
Quality standard:Export standard
Assay: 99%min
MF:C18H19Cl2NO4
Use:calcium antagonist
Appearance: White Crystaline  Powder

 

Specifications

Tests

Specifications

Results

Description

White to yellowish powder, very hygroscopic.

Off-white powder, very hygroscopic.

Solubility

Freetly soluble In water and methanol and dichloromethane

Complies

Identification

       (1)By IR, To match with working standard

Complies

              (2)It gives reaction of sodium

Complies

Impurities A

≤0.1%

Not   detected

Related compounds

Any impurity   ≤0.1%

<0.1%

Total impurities ≤0.4%

0.25%

Residual Solvents

Acetidin≤ 0.5%

Not detected

Dichloromethane≤ 0.06%

Not detected

Methanol≤ 0.3%

Not detected

Acetone ≤ 0.5%

Not detected

Acetonitrile≤0.041%

Not detected

Ethanol≤0.5%

0.04%

N, N-dimethylformamide≤0.088%

Not detected

Water

≤ 5.0%

1.38%

Assay

99.0%-101.0%(On anhydrous basis)

99.98%

Conclusion

Conform to EP8.0

 

Application:

 

Used for the treatment of high blood pressure is a selective calcium antagonists, inhibit the main flow of extracellular calcium arterial smooth muscle cells, and selective expansion of small arteries, veins, no such effect, not cause orthostatic hypotension; myocardial also. no significant inhibition. This product reduces renal vascular resistance, while not affect glomerular filtration rate and creatinine clearance rate, renal blood flow did not change even slightly increased, there natriuretic and diuretic effect. It can be used to increase output and cardiac index, significantly reducing afterload, while the systolic function, preload and heart rate had no significant effect.