RAD 140 SARMS-Powder CAS 1182367-47-0 Lingding470

CAS: 1182367-47-0
MF: C20H16ClN5O2
MW: 393.83
EINECS: 1592732-453-0


Boiling point 687.7±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
pka 13.76±0.20(Predicted)

Categories:

Application & Function

RAD140 is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.
We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.
Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expressio.

RAD 140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM)

Package & Trade Terms

Package: 25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients

Storage Condition: 2-8°C

Supply Ability: 10000.00KG/Month

Trade Terms: FOB,CIF,CIP,EXW

Shipping Mode: By Sea,By Air

Shipping Port: Tianjin

Payment Terms: T/T,Western Union