Tadalafil Cialis powder CAS 171596-29-5 with safe delivery

Melting point 298-300°C
Alpha D20 +71.0°
Boiling point 679.1±55.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
Fp 2℃
Storage temp. Sealed in dry,2-8°C
Solubility DMSO: soluble20mg/mL, clear
Pka 16.68±0.40(Predicted)
Form powder
Color white to beige

Categories:

Product Name: Tadalafil
CAS: 171596-29-5
MF: C22H19N3O4
MW: 389.4
EINECS: 687-782-2

Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.

Description:

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

Uses:

Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.